Evolving the approach to ​MSL targeting

2 mins read
20 May 2025

The Challenge​

  • Historically, MSL Focus Lists have been geared towards Scientific Key Opinion Leaders (KOLs), who are practice or ​TA experts that educate their peers through papers, congresses/lectures, and act as editors of publications. ​This approach alone may miss the opportunity to integrate ​real-world insights from community HCPs. ​
  • To bridge the gap between science and practice, an enhanced strategy is needed to maintain relationships with Scientific KOLs while identifying Community KOLs who influence local adoption of therapies.

Our Solution​

Propensity4 developed a dual arch-typing approach​

  1. Clinical Archetyping: Focus on Scientific KOLs for high-level scientific dialogue. ​
  2. Community Archetyping: Identify Community KOLs ​influencing local prescribing behaviors. ​
  3. Integrated Targeting: Prioritize individuals who “practice what they teach,” combining scientific expertise and practical influence.

The Results

  • Enhanced engagement by bridging science and practice. ​
  • Improved alignment of MSL resources with high-value targets. ​
  • Streamlined geographic coverage for impactful interactions.

Combining Clinical and Community KOLs transforms MSL targeting, enabling impactful engagement that advances therapeutic adoption and patient outcomes.

Case Example: ​Dermatology Analysis

  • Analysis of 735 client identified Clinical KOLs with all HCP biologic prescribers revealed 50% of Clinical KOLs aligned within the top 6 Community KOL archetypes.​
  • In our final analysis, all Clinical KOLs were promoted to “Priority” to maintain critical Clinical KOL relationships and simplify the broader MSL engagement strategy.